I had dogs and cats all my live. My children have also grown up with animals. We have been fostering both cats and dogs from local shelters for the past 6-7 years. We have had anything from a small Yorkie to a large Rotti mix. We have a 4 yr old Mastiff mix who loves other dogs and loves to play with anything. Size does not matter to him. There is no food or toy aggression in my house. I have both cats and dogs and everyone gets along fine. We have had many animals in our care who have had to have medicine for one reason or another and we have not had any problems administering. We have a fully fenced yard with a pool where the dogs can run and play.