Have traveled around the midwest and south with our Pyr - as long as the weather is cooler (as in not summer) she is fine. Watch the fine print on hotels that claim to be pet friendly - many will only take up to 20 lbs or so. The dog sleeps in the back of the mini-van when we go out for dinner - as long as it is cool / cold weather. Can't do that when it is hot so summers we would be stuck with fast food as hotels do not want dogs left unattended in your room. Just a note - National Parks are not pet friendly, nor are many beach communities, so be sure to do your research.