Adaptil which is a synthetic pheromone which I've personally seen work wonders. Of course every scenario is different some babies are more high strung or anxious than others. But, Adaptil comes in wipes, oils (that you can plug up in your home), spray bottles and collars. It's a different form of communication for your doggy, it provides a calming environment for them! I work in a Animal Hospital, and in some cases doctors will prescribe a mild sedative for traveling purposes as well.

Much success.

Jasmin