I have two dogs (one of whom can be dog-reactive on leash - hyperfocused, bossy, and defensive of her space) and I watch up to two others at a time. I always do introductions one on one outside, first with my mellow girl, followed by my more challenging girl, and don't allow the dogs to sniff each other more than a couple seconds before separating them, trying to time it so neither dog gets nervous, tense, or snarky. Then we take them for a group walk, at first preventing the dogs from interacting with each other, and slowly allowing them to sniff and walk side by side as they settle down. By the time we've gotten back to my house, the dogs are comfortable and calm with each other 95% of the time. I allow the client and their dog to come inside at this point and let their dog explore while either keeping my dog on leash, in the kennel, or under verbal control, not allowing my dog to pester the guest, but allowing them to interact with each other should they both want to.
When they are dropped off for the stay, I usually have my dog(s) kenneled so the new guest has the opportunity to investigate everything on their own terms, then take them all out for another group walk. After that, everyone is very closely supervised and separated as necessary if someone starts getting a little stressed or overwhelmed with the group. In most instances the dogs are completely comfortable with each other within the first day. I've had only very minimal conflict with the dogs I've watched and no injuries, and I've only turned down one client due to dog incompatibility, which might have been manageable, but I did not deem it to be worth the effort or the stress on my dogs. It's their house, too, so I'm not going to put them in an uncomfortable position if it isn't necessary, and since their social skills are generally quite good (minus a couple quirks that we actively work on), I don't see the need in forcing them to spend time with a dog they just don't like in their house. It's worth pointing out that the one dog I turned down did not want to do a group leashed walk during the M&G due to leash reactivity with her own dog, so in my experience this method of using gradual introductions and group walks has resulted in a very high success rate.